The ARCH has enabled the CIC to refocus its activity on its associated and Inserm-labeled topics. The structure aims at ensuring the support of the so-called "service" activities and has developed ARO (Academic Research Organization) activities over the years.
For the hospital teams that are already structured, the ARCH can meet complex requests (biological sampling on call) or occasional needs. For investigators without clinical research resources, it offers a more comprehensive service from the building of projects to their completion.
From a logistical point of view, in order to be able to cover service outside the hospital walls, with the idea that the research pathway must adapt to the care pathway, the ARCH has 2 dedicated vehicles with a mobile team of research nurses. It allows us to collect samples at home, and to collect data or biological samples in accordance with Good Clinical Practice.
Some clinical research protocols require the implementation of on-call nurses: monitoring of a patient in a protocol 24h a day, close pharmacokinetic sampling, etc... Some others, especially the protocols in intensive care, require inclusion at night or on weekends. In order to provide continuity of clinical research 7/24/365, official operational on-call duties are therefore provided by the clinical research nurses of the CIC/ARCH. Every new nurse is trained to the on-call duty.
Thanks to its experience in Infectious Diseases trials, the CIC team includes personnel who have developed real expertise in this field (understanding of the intensive care environment, familiarity with the files and medical data collected, knowledge of the pathologies and treatments allocated, understanding of adverse effects, etc.)
More and more frequently, as part of the missions delegated by some sponsors, the CIC must address requests to ensure quality monitoring.
Created in 2017, the Monitoring Unit for Sepsis Trials (MUST) is therefore intended to provide external monitoring services by personnel who are independent of the research activities, within the framework of national and international clinical trials coordinated by the CIC in the field of sepsis and infectious diseases in critically ill patients.
The territorial portal of the ARCH is organized around several activities:
The aim of this mission is to support and assist institutions without a Clinical Research Management (non-university institutions, clinics, etc....), both public and private, in their clinical research activities. To do this, personnel time for clinical research is made available to these sites, calls for proposals and feasibility studies are regularly transmitted, and training sessions on clinical research and research in care are organized for the staff.
The purpose of this network created in 2014 is to structure a regional dynamic around Sepsis with the idea of setting up, not only a care pathway (such as what is done fro stroke, for example) with harmonized management, but also a clinical research dynamic. Several protocols carried out or coordinated by the Limoges University Hospital have already been implemented in some regional institutions. A training component is added to this with scientific meetings several times a year within the different institutions of the network.
A "Clinic/University Hospital Interface" mission was set up in 2008 to develop clinical research in the field of Oncology at the Limoges Polyclinic.
In line with this mission, the EMRC (Mobile Clinical Research Team) was set up following the call for proposals issued by the INCa in 2006, allowing funding of personnel and supporting clinical research in oncology in the region's institutions. Study proposals are regularly sent to other investigators in the region. The EMRC also works with the regional cancer network ROHLim.
For more information, visit: https://www.e-cancer.fr/Professionnels-de-la-recherche/Recherche-clinique/Soutien-a-la-recherche-clinique/Les-EMRC
This clinical research network includes general practitioners in the region and was created in 2014 by the ARCH with the aim of providing a broad area of primary care to a population that has little or no access to rigorous scientific investigations. Thus, the structure provides qualified personnel (project managers, CRAs and clinical research nurses) to the physicians in the network, while facilitating theadministrative circuits, which are often cumbersome and complex, in particular by offering a single contact to the Sponsors.